In March 2025, CEA launched Audace!, an ambitious research program backed by €40 million from France 2030 and requested by the French government. The initiative mobilizes all of CEA’s research fields and more than 80 academic partners across France, supporting around 10 projects designed to inject new scientific concepts into CEA labs and remove technological barriers to promising technologies.

CEA-Leti is one of the program’s key contributors, working on a brain-computer interface-based therapy for post-stroke rehabilitation through the BrainSync project. The effort builds on WIMAGINE®, CEA’s brain-machine interface technology, which has already enabled two landmark demonstrations published in The Lancet Neurology and Nature.

In 2019, the system allowed a tetraplegic patient to control a four-limb exoskeleton using brain activity. In 2023, it helped a paraplegic patient regain natural walking control by combining WIMAGINE® with an implanted spinal cord stimulation therapy developed by EPFL, CHUV, UNIL and ONWARD Medical in Lausanne, Switzerland.

CEA-Leti software manager Serpil Karakas is now extending this work toward a neurorehabilitation platform for post-stroke patients, with a particular focus on people with limited upper-limb mobility and motor impairment. The goal is to enable rehabilitation sessions driven by brain activity and responsive feedback.

According to neurotechnology researcher Lucas Struber, CEA-Leti, Grenoble University Hospital and Saint-Étienne University Hospital have already applied for regulatory authorization to launch a clinical trial. The rehabilitation concept relies on real-time coupling between detected motor intention in brain signals and sensorimotor feedback such as stimulation, robotic assistance or virtual feedback. By repeatedly linking intention and feedback, the approach is intended to promote neuroplasticity, strengthen relevant neural pathways and potentially improve functional recovery.

Beyond French state support through Audace!, the CEA-Leti team is also receiving backing from the European Commission via a European Innovation Council grant under Horizon Europe.

​​​​​​​​​​​In March 2025, CEA launched a bold and ambitious research programAUDACEthat mobilizes allCEA research fields, as well as over 80 academic partners throughout France supporting around 10 projects.

​Begun at the request of the French government with funding of €40 million under France 2030, Audace! aims to bring new scientific concepts to CEA labs and to remove technological barriers to development of promising technologies. CEA-Leti's participation includes development on a brain-computer interface new therapy for poststroke rehabilitation in the context of theBrainSyncproject.

​The unique WIMAGINE®brain–machine interface technology has already contributed to two world-first achievements published inThe LancetNeurologyandNature.

In 2019, a tetraplegic patient was able to use brain activity to control a four-limb exoskeleton. In 2023, a paraplegic patient regained natural control of walking through the combination of CEA's WIMAGINE®technology with an implantedspinal cord stimulation therapy developed by EPFL, CHUV, UNIL, and ONWARD Medical (Lausanne, Switzerland).

Serpil Karakas, software manager at CEA-Leti, is now exploring the use of this technology to develop a neurorehabilitation platform that would enable post-stroke patients to carry out rehabilitation sessions. This approach is particularly aimed at patients with limited upper-limb mobility, especially those experiencing motor impairment.

Neurotechnology researcher Lucas Struber said CEA-Leti, Grenoble University Hospital and Saint-Étienne University Hospital have applied for authorization from regulatory authorities to conduct a clinical trial aimed at enabling post-stroke rehabilitation using these BCI. The principle of a BCI for rehabilitation relies on establishing a real-time coupling between detected motor intention in brain activity and corresponding sensorimotor feedback (e.g., stimulation, robotic assistance, or virtual feedback). This repeated association could promote neuroplasticity by strengthening relevant neural pathways, thereby potentially supporting functional recovery potential.

In addition to support from the French government under the Audace! program, the CEA-Leti team's work is supported by the European Commission through a grant from the European Innovation Council (EIC) under the Horizon Europe program.

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